GSK-J1, JMJ H3K27 Demethylase inhibitor (Non-cell permeable)

SKU
G-2641
  • CAS:1373422-53-7
  • Formula:C22H23N5O2
  • MW:389.46
  • Appearance:Pale yellow solid
  • Purity:99% by TLC NMR (Conforms)
Product Name Qty
GSK-J1, JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
25 mg
$313.96

GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).

More Information
SKU
G-2641
CAS #
1373422-53-7
Chemical Name
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Chemical Formula
C22H23N5O2
Molecular Weight
389.46
Appearance
Pale yellow solid
Purity
99% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 20 mg/ml).
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Storage Temp
RT (des.)
Hazard Image
Yes
Promo text for AGS discount
N/A
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