GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable)

SKU
G-2643
  • CAS:1373423-53-0
  • Formula:C24H27N5O2
  • MW:417.48
  • Appearance:Yellow waxy solid
  • Purity:99% by TLC NMR (Conforms)

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Product Name Qty
GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable)
25 mg
$320.24

GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393). GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

More Information
Alternate Name/Synonyms
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
SKU
G-2643
CAS #
1373423-53-0
Chemical Name
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Chemical Formula
C24H27N5O2
Molecular Weight
417.48
Appearance
Yellow waxy solid
Purity
99% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Storage Temp
-20°
Hazard Image
Yes
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