GW2580

SKU
G-2347
  • CAS:870483-87-7
  • Formula:C20H22N4O3
  • MW:366.41
  • Appearance:Off-White Solid
  • Purity:99% by HPLC
Product Name Qty
GW2580
5 mg
$85.43
GW2580
25 mg
$336.03
A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.
More Information
Alternate Name/Synonyms
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
SKU
G-2347
CAS #
870483-87-7
Chemical Name
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Chemical Formula
C20H22N4O3
Molecular Weight
366.41
Appearance
Off-White Solid
Purity
99% by HPLC
Solubility
Soluble in DMSO (40 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Not Available
MDL NUMBER
MFCD12024701
CHEMACX
X1829250-9
INCHI
InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
SMILES
COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Certificate of Analysis 1
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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