H-7 Dihydrochloride

SKU

H-1020

CAS:108930-17-2
Formula:C₁₄H₁₇N₃O₂S • 2HCl
MW:364.29
Appearance:White to off-white crystalline solid
Purity:≥98% by HPLC

SDS

CofA

Product Name	Qty
H-7 Dihydrochloride 5 mg $102.80
H-7 Dihydrochloride 25 mg $416.61

Details

Description

Potent inhibitor of PKA (Ki=3.0 μm), PKC (Ki=6 μm), PKG (Ki=5.8 nM), and myosin light chain kinase (Ki=97 μm). Selectivity for PKC can achieved when used in conjunction with HA-1004.

Attached is a published reference from researchers who have used our H-7 Dihydrochloride:

• EXPERIMENTAL AND MOLECULAR MEDICINE/ONCOLOGY/PATHOLOGY: Polyenoic Fatty Acid Ratios Alter Fibroblast Collagen Production Via PGE2 and PGE Receptor Subtype Response, Yi Jia and John J. Turek, Exp Biol Med, Jul 2004; 229: 676 - 683.

Specifications

More Information

Alternate Name/Synonyms

1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride

SKU

H-1020

CAS #

108930-17-2

Chemical Name

5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;dihydrochloride

Chemical Formula

C₁₄H₁₇N₃O₂S • 2HCl

Molecular Weight

364.29

Appearance

White to off-white crystalline solid

Purity

≥98% by HPLC

Solubility

DMSO (>20 mg/mL) or water (>20 mg/mL)

Melting Point

N/A

Preparation

N/A

Storage Temp

-20°C

USE

Protein kinase inhibitor

Merck Index

N/A

RTECS

N/A

Handling

Thermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.

Certificate of Analysis 1

H-1020, J1159.pdf

Certificate of Analysis 2

H-1020, E1378.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Thermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.

Citations