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H-7 Dihydrochloride

SKU
H-1020
  • CAS:108930-17-2
  • Formula:C14H17N3O2S • 2HCl
  • MW:364.29
  • Appearance:White to off-white crystalline solid
  • Purity:≥98% by HPLC
Product Name Qty
H-7 Dihydrochloride
5 mg
$107.26
H-7 Dihydrochloride
25 mg
$434.72
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Description

Potent inhibitor of PKA (Ki=3.0 μm), PKC (Ki=6 μm), PKG (Ki=5.8 nM), and myosin light chain kinase (Ki=97 μm). Selectivity for PKC can achieved when used in conjunction with HA-1004.

Attached is a published reference from researchers who have used our H-7 Dihydrochloride:

• EXPERIMENTAL AND MOLECULAR MEDICINE/ONCOLOGY/PATHOLOGY: Polyenoic Fatty Acid Ratios Alter Fibroblast Collagen Production Via PGE2 and PGE Receptor Subtype Response, Yi Jia and John J. Turek, Exp Biol Med, Jul 2004; 229: 676 - 683.

More Information
Alternate Name/Synonyms
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride
SKU
H-1020
CAS #
108930-17-2
Chemical Name
5-(2-methylpiperazin-1-yl)sulfonylisoquinoline;dihydrochloride
Chemical Formula
C14H17N3O2S • 2HCl
Molecular Weight
364.29
Appearance
White to off-white crystalline solid
Purity
≥98% by HPLC
Solubility
DMSO (>20 mg/mL) or water (>20 mg/mL)
Storage Temp
-20°C
USE
Protein kinase inhibitor
Handling
Thermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
H-1020, J1159.pdf
Certificate of Analysis 2
H-1020, E1378.pdf
GHS PICTOGRAMS
HandlingThermal decomposition can lead to release of toxic/corrosive gases and vapors. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
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