Herbimycin C

SKU
H-2471
  • CAS:91700-92-4
  • Formula:C29H40N2O9
  • MW:560.6 Da
  • Appearance:Yellow solid
  • Purity:>98% by HPLC
Product Name Qty
Herbimycin C
0.5 mg
$339.12
Herbimycin C
2.5 mg
$1,199.98

Description

Herbimycin C is a minor analogue of the herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and converts Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin, has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs.

More Information
Alternate Name/Synonyms
TAN 420D
SKU
H-2471
CAS #
91700-92-4
Chemical Name
[(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-13-hydroxy-8,14,17-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Chemical Formula
C29H40N2O9
Molecular Weight
560.6 Da
Appearance
Yellow solid
Purity
>98% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO Limited water solubility
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Minor analog of the herbimycin complex with potent antitumor activity
MDL NUMBER
MFCD14635436
INCHI
InChI=1S/C29H40N2O9/c1-15-9-8-10-22(37-5)27(40-29(30)36)17(3)11-16(2)24(33)23(38-6)12-18(4)26(39-7)20-13-19(32)14-21(25(20)34)31-28(15)35/h8-11,13-14,16,18,22-24,26-27,33H,12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,15-9+,17-11+/t16-,18-,22-,23-,24+,26+,27-/m0/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)\C)C)O)OC
Handling
Handle in accordance with good industrial hygiene and safety practice. Keep containers tightly closed in a dry, cool and well-ventilated place.
HandlingHandle in accordance with good industrial hygiene and safety practice. Keep containers tightly closed in a dry, cool and well-ventilated place.
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