Hypothemycin

SKU
H-2403
  • CAS:76958-67-3
  • Formula:C19 H22 O8
  • MW:378.375
  • Appearance:Solid
  • Purity:98% (HPLC)
Product Name Qty
Hypothemycin
250 ug
$148.07
Hypothemycin
1 mg
$444.23

The resorcyclic acid lactone Hypothemycin isolated from Phoma sp. has antifuangal and anticancer activity.

Hypothemycin normalized the morphology and inhibited anchorage-independent growth of Ki-ras transformed normal rat kidney(NRK) cells with selectivity and potency comparable to or greater than that of the MEK inhibitor U0126. It is also potent and selective threonine/tyrosine-specific kinase.

Hypothemycin inhibits proliferation of mouse and human T-cells and modulates production of cytokines during T-cell activation. It facilitates the ubiquitinylation process of cyclin D1.

 

Product References

 

More Information
SKU
H-2403
CAS #
76958-67-3
Chemical Formula
C19 H22 O8
Molecular Weight
378.375
Appearance
Solid
Purity
98% (HPLC)
Solubility
Soluble in DMSO or acetone; insoluble in methanol or water
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Hypothemycin exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes
CHEMACX
X1867744-0
INCHI
InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
SMILES
C[C@H]1C/C=CC(=O)[C@H]([C@H](C[C@@H]2[C@H](O2)C3=C(C(=CC(=C3)OC)O)C(=O)O1)O)O
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