IBMX is a potent, non-selective inhibitor of phosphodiesterases (PDE 1,2,3,4,5).
It has been reported that IBMX has an adipogenic effect mediated by suppression of endogenous TNF production. In cultured human preadipocytes and adipocytes, TNF-mRNA expression is suppressed by IBMX.
It is believed that IBMX is related to glucose mechanisms. In diabetic rat models, response of 5’-cyclin monophosphate (cAMP) to glucose and secretion of glucose-induced insulin failed. Addition of IBMX in these models helps them recover their function, accumulating cAMP and releasing insulin responding to glucose.
In neural cells, it has been shown that IBMX transiently elevates the level of Ca2+ from intracellular stores.
• Inhibitor of PDE1, PDE2, PDE3, PDE4, PDE5
• Studies of cAMP
• Studies of Ca2+ in neural cells
Not for human therapeutic use or for medicinal purposes. For research applications only.
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