IBMX

SKU
I-1036
  • CAS:28822-58-4
  • Formula:C10H14N4O2
  • MW:222.24 Da
  • Appearance:White Solid
  • Purity:≥99%

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Product Name Qty
IBMX
500 mg
$115.17
IBMX
1 g
$235.10
IBMX
200 mg
$55.81

Description

IBMX is a potent, non-selective inhibitor of phosphodiesterases (PDE 1,2,3,4,5).

It has been reported that IBMX has an adipogenic effect mediated by suppression of endogenous TNF production. In cultured human preadipocytes and adipocytes, TNF-mRNA expression is suppressed by IBMX.

It is believed that IBMX is related to glucose mechanisms. In diabetic rat models, response of 5’-cyclin monophosphate (cAMP) to glucose and secretion of glucose-induced insulin failed. Addition of IBMX in these models helps them recover their function, accumulating cAMP and releasing insulin responding to glucose.

In neural cells, it has been shown that IBMX transiently elevates the level of Ca2+ from intracellular stores.

 

Applications

• Inhibitor of PDE1, PDE2, PDE3, PDE4, PDE5

• Studies of cAMP

• Studies of Ca2+ in neural cells

 

References

• “Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP”

• “IBMX induces calcium release from intracellular stores in rat sensory neurons”

• “The Phosphodiesterase Inhibitor IBMX Suppresses TNF-α Expression in Human Adipocyte Precursor Cells: A Possible Explanation for its Adipogenic Effect”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
isobutylmethylxanthine; Methylisobutylxanthine
SKU
I-1036
CAS #
28822-58-4
Chemical Name
1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
Chemical Formula
C10H14N4O2
Molecular Weight
222.24 Da
Appearance
White Solid
Purity
≥99%
Solubility
Soluble in DMSO (15 mg/ml) or ethanol (10 mg/ml)
Melting Point
200-201°C
Storage Temp
Room Temperature
THERAPEUTIC AREA
Not Applicable
USE
IBMX is one of the most potent and nonspecific inhibitors of cyclic nucleotide PDE (phosphodiesterases) with documented IC50 values for PDE1, 2, 3, 4, and 5 equaling 19, 50, 18, 13 and 32. The compound is documented to raise intracellular cyclic AMP levels. In rat sensory neurons the addition of IBMX caused the release of Ca2+ from caffeine ryanodine sensitive internal stores increasing the internal Ca2+ levels and inducing a biphasic membrane current response. Through PDE inhibition IBMX has also inhibited TNFα. IBMX in breast cancer cells has also induced p21 and p27 through a PKA independent pathway. Although a nonspecific PDE inhibitor IBMX does not show inhibition of PDE8B. In neuroendocrine epithelial cells IBMX has been observed to inhibit α-adrenoceptor-mediated 5-HT release at IC50 = 1.3μM.
MDL NUMBER
MFCD00005584
CHEMACX
X1379365-0
INCHI
InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
SMILES
CC(C)Cn1c2c(c(=O)n(c1=O)C)[nH]cn2
RTECS
ZD8500000
Handling
Store in Tightly Sealed Vial
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial
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