Ibuprofen

SKU
I-2427
  • CAS:15687-27-1
  • Formula:C13 H18 O2
  • MW:206.3
  • Appearance:White powder
  • Purity:>99% (TLC); NMR (Conforms)
Product Name Qty
Ibuprofen
inquire
$0.00

Ibuprofen is a non-steroidal anti-inflamatory drug used commonly as a pain killer, fever reducer and to relieve symptoms of arthritis, such as swelling, stiffness and joint pain. Ibuprofen non-selectively and reversibly inhibits cyclooxyganase enzymes COX-1 and COX-2.

Archadonic acid that is released from the cell mebrane is converted to an unstable intermediates prostagladin H- COX-1 and COX-2. These are converted by tissue specific synthases to various prostanoids. The prostanoids exert different biological effects through corresponding receptors. Not only does Ibuprofen exert its anti-inflammatory effect by inhibiting COX-1 and 2, it also triggers anti-nociceptive effects by inhibitng fatty acid amide hydrolase.

Epidemiological studies have suggested reduction in the risk of Alzheimers disease (AD) with the use of NSAID's, prompting further research by administering oral ibuprofen to transgenic mice model of AD. The results showed evidence that ibuprofen can significantly delay some forms of AD pathology such as amyloid deposition.

More Information
Alternate Name/Synonyms
α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propionic acid
SKU
I-2427
CAS #
15687-27-1
Chemical Formula
C13 H18 O2
Molecular Weight
206.3
Appearance
White powder
Purity
>99% (TLC); NMR (Conforms)
Solubility
May be dissolved in DMSO (25 mg/ml)
Melting Point
75-77°C
Storage Temp
Store at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months
THERAPEUTIC AREA
Pain / Analgesia
USE
Ibuprofen inhibits Cox (cyclooxygenase) selectively, targeting Cox-1 (PGH synthase-1) and Cox-2 (PGH synthase-2) useful as a non-steroidal anti-inflammatory
MDL NUMBER
MFCD00010393
CHEMACX
X1000393-1
INCHI
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
SMILES
CC(C)Cc1ccc(cc1)C(C)C(=O)O
RTECS
MU6640000
UN #'S
UN 3077
PACKING GROUP
III
UN #'SUN 3077
Packing GroupIII
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