Imatinib mesylate

SKU
I-2359
  • CAS:220127-57-1
  • Formula:C29H31N7O.CH4SO3
  • MW:589.71
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC

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Product Name Qty
Imatinib mesylate
100 mg
$99.34
Imatinib mesylate
1 g
$369.75

An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC= 0.5 nM), phosphorylation of a fusion protein (IC= 30 nM), and viability of BaF3 cells expressing Rhe-PDGFR in the absence of IL-3 (IC= 0.17 nM).

More Information
Alternate Name/Synonyms
CGP-57148B, STI-571
SKU
I-2359
CAS #
220127-57-1
Chemical Name
N-(4-METHYL-3-((4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)-4-((4-METHYLPIPERAZIN-1-YL)METHYL)BENZAMIDE METHANESULFONATE
Chemical Formula
C29H31N7O.CH4SO3
Molecular Weight
589.71
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO (100 mg/ml)
Melting Point
214-224 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity
MDL NUMBER
MFCD04307699
CHEMACX
X1493265-9
INCHI
InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
SMILES
Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)NC(=O)c4ccc(cc4)CN5CCN(CC5)C.CS(=O)(=O)O
RTECS
CV5585673
Handling
Protect from air and moisture
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Protect from air and moisture
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