Ubiquitin function inhibitors interfere with the process of ubiquitination. Ubiquitin is a small regulatory protein and adhere to a substrate protein. Thereby, ubiquitination occurs. Ubiquitination has many effects, including protein degradation via the proteasome, promoting or preventing protein interactions, and altering cellular location of proteins. Activation, conjugation, and ligation are three main steps of ubiquitination.
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