Ionomycin, Free Acid

SKU

I-1014

CAS:56092-81-0
Formula:C₄₁H₇₂O₉
MW:709 Da
Appearance:Waxy colorless to yellow material
Purity:≥99%

SDS

CofA

Product Name	Qty
Ionomycin, Free Acid 5 mg $347.41
Ionomycin, Free Acid 1 mg $91.13

Details

Ionomycin, free acid, is a highly specific ionophore useful in studying Ca2+ transportation. FromStreptomyces conglobatus. Highly specific ionophore useful in studying Ca2+ transportation.The Mitochondrial Permeability Transition Regulates Cytochrome c Release for Apoptosis during Endoplasmic Reticulum Stress by Remodeling the Cristae Junction.HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function.Frequent and Strong Antibody-Mediated Natural Killer Cell Activation in Response to HIV-1 Env in Individuals with Chronic HIV-1 Infection.LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.Immune-driven recombination and loss of control after HIV superinfection.

Specifications

More Information

SKU

I-1014

CAS #

56092-81-0

Chemical Name

(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid

Chemical Formula

C₄₁H₇₂O₉

Molecular Weight

709 Da

Appearance

Waxy colorless to yellow material

Purity

≥99%

Solubility

DMSO/DCM/CH₃OH: clear colorless solution at 10 mg/ml

Melting Point

N/A

Preparation

N/A

Storage Temp

+4°C

THERAPEUTIC AREA

Antibacterial

USE

Ionomycin free acid is an antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that this antibiotic can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane.

Merck Index

N/A

MDL NUMBER

MFCD06798385

CHEMACX

X1098403-1

INCHI

InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1

SMILES

C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)O

RTECS

NO0600000

Handling

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.

Citations

BRIEF DEFINITIVE REPORTS: Immune-driven recombination and loss of control after HIV superinfection Hendrik Streeck, Bin Li, Art F.Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D.W. Frost, Marcus Altfeld, and Todd M. Allen J. Exp. Med., Aug 2008; 205: 1789 - 1796.

Citations_Hyperlink

http://jem.rupress.org/cgi/reprint/205/8/1789

msds 1

I-1014, Ionomycin, SDS, diamond format.pdf

Certificate of Analysis 1

I-1014, H1300A.pdf

Certificate of Analysis 2

I-1014, H1300.pdf

Certificate of Analysis 3

I-1014, G1054A.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.

Citations

Citations	LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation
	Immune-driven recombination and loss of control after HIV superinfection
	Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
	Syndecan-4 promotes the retention of phosphatidylinositol 4,5-bisphosphate in the plasma membrane
	Rapid ex vivo isolation and long-term culture of human Th17 cells
	Mammalian Egg Activation: The Roles of TRPV3 Channels and PLCZ1

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