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Ionomycin, Free Acid

SKU
I-1014
  • CAS:56092-81-0
  • Formula:C41H72O9
  • MW:709 Da
  • Appearance:Waxy colorless to yellow material
  • Purity:≥99%
Product Name Qty
Ionomycin, Free Acid
1 mg
$93.22
Ionomycin, Free Acid
5 mg
$355.40
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Description

Ionomycin is a highly specific ionophore isolated from Streptomyces conglobatus. It acts as a transport carrier of divalent cations, helping the cations across solvent barriers. It is used to study calcium transport across the plasma membrane.

It is known to induce apoptosis in some cell lines. For example, it is reported that ionomycin promotes apoptosis in immature B cells and regulates cell cycle in mature B cells. It is also believed that the ionophore induces apoptotic degeneration of embryonic cortical neurons.

Ionomycin is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA.

 

Applications

• Ca2+ ionophore

• Antibiotic

 

References

• “Regulation of cell division of mature B cells by ionomycin and phorbol ester.”

• “Characterization of ionomycin as a calcium ionophore.”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
SKU
I-1014
CAS #
56092-81-0
Chemical Name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
Chemical Formula
C41H72O9
Molecular Weight
709 Da
Appearance
Waxy colorless to yellow material
Purity
≥99%
Solubility
DMSO/DCM/CH3OH: clear colorless solution at 10 mg/ml
Storage Temp
+4°C
THERAPEUTIC AREA
Antibacterial
USE
Ionomycin free acid is an antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that this antibiotic can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane.
MDL NUMBER
MFCD06798385
CHEMACX
X1098403-1
INCHI
InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
SMILES
C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)O
RTECS
NO0600000
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Citations
BRIEF DEFINITIVE REPORTS: Immune-driven recombination and loss of control after HIV superinfection Hendrik Streeck, Bin Li, Art F.Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D.W. Frost, Marcus Altfeld, and Todd M. Allen J. Exp. Med., Aug 2008; 205: 1789 - 1796.
Citations_Hyperlink
http://jem.rupress.org/cgi/reprint/205/8/1789
msds 1
I-1014, Ionomycin, SDS, diamond format, r01, 2020.pdf
Certificate of Analysis 1
I-1014, E1377 pt2.pdf
Certificate of Analysis 2
I-1014, L1295.pdf
Certificate of Analysis 3
I-1014, L1088.pdf
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
CitationsLIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation
Immune-driven recombination and loss of control after HIV superinfection
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
Syndecan-4 promotes the retention of phosphatidylinositol 4,5-bisphosphate in the plasma membrane
Rapid ex vivo isolation and long-term culture of human Th17 cells
Mammalian Egg Activation: The Roles of TRPV3 Channels and PLCZ1
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