Ionomycin, Free Acid

SKU
I-1014
  • CAS:56092-81-0
  • Formula:C41H72O9
  • MW:709 Da
  • Appearance:Waxy colorless to yellow material
  • Purity:≥99%

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Product Name Qty
Ionomycin, Free Acid
5 mg
$340.60
Ionomycin, Free Acid
1 mg
$89.34

Ionomycin, free acid, is a highly specific ionophore useful in studying Ca2+ transportation. FromStreptomyces conglobatus. Highly specific ionophore useful in studying Ca2+ transportation.The Mitochondrial Permeability Transition Regulates Cytochrome c Release for Apoptosis during Endoplasmic Reticulum Stress by Remodeling the Cristae Junction.HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function.Frequent and Strong Antibody-Mediated Natural Killer Cell Activation in Response to HIV-1 Env in Individuals with Chronic HIV-1 Infection.LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.Immune-driven recombination and loss of control after HIV superinfection.

More Information
SKU
I-1014
CAS #
56092-81-0
Chemical Name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
Chemical Formula
C41H72O9
Molecular Weight
709 Da
Appearance
Waxy colorless to yellow material
Purity
≥99%
Solubility
DMSO/DCM/CH3OH: clear colorless solution at 10 mg/ml
Melting Point
N/A
Preparation
N/A
Storage Temp
Room Temperature
THERAPEUTIC AREA
Antibacterial
USE
Ionomycin free acid is an antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that this antibiotic can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane.
Merck Index
N/A
MDL NUMBER
MFCD06798385
CHEMACX
X1098403-1
INCHI
InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
SMILES
C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)O
RTECS
NO0600000
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Citations
BRIEF DEFINITIVE REPORTS: Immune-driven recombination and loss of control after HIV superinfection Hendrik Streeck, Bin Li, Art F.Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D.W. Frost, Marcus Altfeld, and Todd M. Allen J. Exp. Med., Aug 2008; 205: 1789 - 1796.
Citations_Hyperlink
http://jem.rupress.org/cgi/reprint/205/8/1789
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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