Isofusidienol A was produced by cultures of Chalara sp., an endophytic fungus isolated from Artemisia vulgaris. 

The unprecedented chromone-3-oxepine structure of the compunds was established by detailed spectroscopic analysis and in the case of isofusidienol A verified by an X-ray analysis. 

The isofusidienols exhibit antifungal activity against Candida albicans and antibaterial activity against gram-positive and gram-negative bacteria. Inhibition of Bacillus subtillis could be achieved with less than 0.625 ug of on 6-mm filter disks in plate diffusion assays.

Product References

• Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp., Sandra Losgen, et al, European Journal of Organic Chemistry, vol. 2008,698-703 (2008)