Isozyme-Selective-Akt Inhibitor

SKU
A-1714
  • CAS:612847-09-3
  • Formula:C34H29N7O
  • MW:551.65
  • Appearance:Light yellow Solid
  • Purity:97% by HPLC

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Product Name Qty
Isozyme-Selective-Akt Inhibitor
1 mg
$142.38

Isozyme -selective-Akt inhibitor is a cell-permeable, potent and selective inhibitor of Akt1/Akt2 activity (IC = 58 nM (Akt1), 210 nM (Akt2) and 2.12 M (Akt3) in vitro kinase assays. The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akt's, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 M).

More Information
Alternate Name/Synonyms
1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2
SKU
A-1714
CAS #
612847-09-3
Chemical Name
1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2
Chemical Formula
C34H29N7O
Molecular Weight
551.65
Appearance
Light yellow Solid
Purity
97% by HPLC
Solubility
Soluble in DMSO
Melting Point
242-245 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
A cell-permeable Akt1/2 inhibitor with improved solubility and Ak2 selectivity
MDL NUMBER
MFCD09026909
CHEMACX
X1607009-4
INCHI
InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=C(C=C7C(=C6)NC=N7)N=C5C8=CC=CC=C8
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and moisture
GHS PICTOGRAMS
Handling Protect from air and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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