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Ivermectin B1a

SKU
I-2573
  • CAS:71827-03-7
  • Formula:C48H74O14
  • MW:875.1 Da
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Ivermectin B1a
1 mg
$223.73
Ivermectin B1a
5 mg
$783.06
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Description

Ivermectin B1a (dihydroavermectin B1a) is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.

References

• Ivermectin, a new broad-spectrum antiparasitic agent

• Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics

• Avermectin\milbemycin resistance in trichostrongyloid nematodes

• Ivermectin: a potent new antiparasitic agent

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Dihydroavermectin B1a; Ivermectin; 22,23-Dihydroavermectin B1a
SKU
I-2573
CAS #
71827-03-7
Chemical Formula
C48H74O14
Molecular Weight
875.1 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Ivermectin B1a (dihydroavermectin B1a) is the major component of the commercial anthelmintic
MDL NUMBER
MFCD00869511
INCHI
InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
SMILES
CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
Handling
Avoid prolonged or repeated exposure.
HandlingAvoid prolonged or repeated exposure.
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