Ivermectin B1a aglycone

SKU
I-2575
  • CAS:123997-59-1
  • Formula:C34H50O8
  • MW:586.8 Da
  • Appearance:White solid
  • Purity:>99% by HPLC

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Product Name Qty
Ivermectin B1a aglycone
1 mg
$355.39
Ivermectin B1a aglycone
5 mg
$1,243.86

Description

Ivermectin aglycone is a semi-synthetic produced by hydrolysing the disaccharide unit of ivermectin. Ivermectin aglycone is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. The aglycone is used as a sensitive probe for the detection of some types of ivermectin resistance.

References

Ivermectin, a new broad-spectrum antiparasitic agent

Detection of resistance to ivermectin in haemonchus contortus

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Dihydroavermectin B1 aglycone; Ivermectin B1 aglycone
SKU
I-2575
CAS #
123997-59-1
Chemical Formula
C34H50O8
Molecular Weight
586.8 Da
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Used as a sensitive probe for the detection of some types of ivermectin resistance
MDL NUMBER
MFCD14635437
INCHI
InChI=1S/C34H50O8/c1-7-19(2)30-22(5)13-14-33(42-30)17-26-16-25(41-33)12-11-21(4)28(35)20(3)9-8-10-24-18-39-31-29(36)23(6)15-27(32(37)40-26)34(24,31)38/h8-11,15,19-20,22,25-31,35-36,38H,7,12-14,16-18H2,1-6H3/b9-8+,21-11+,24-10+/t19-,20-,22-,25+,26-,27-,28-,29+,30+,31+,33+,34?/m0/s1
SMILES
CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5C4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O)\C)C
Handling
Handle in accordance with good industrial hygiene and safety practice.
Handling Handle in accordance with good industrial hygiene and safety practice.
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