Ivermectin B1b

SKU
I-2583
  • CAS:70209-81-3
  • Formula:C47H72O14
  • MW:861.1 Da
  • Appearance:White solid
  • Purity:>95% by HPLC

0

1

0

Product Name
No options of this product are available.

INQUIRE FOR PRICING & AVAILABILITY 

Description

Ivermectin B1b (dihydroavermectin B1b) is the minor component (<20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro, the B1b (25-iso-propyl) analogue is slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis, and also a more sensitive probe for ivermectin resistance.

References

Ivermectin, a new broad-spectrum antiparasitic agent

Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics

Avermectin\milbemycin resistance in trichostrongyloid nematodes

Ivermectin: a potent new antiparasitic agent

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Dihydroavermectin B1b; 22,23-Dihydroavermectin B1b; Avermectin H2B1b
SKU
I-2583
CAS #
70209-81-3
Chemical Name
(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.1
Chemical Formula
C47H72O14
Molecular Weight
861.1 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Anthelmintic
Handling
Handle in accordance with good industrial hygiene and safety practice.
Hazard Image
Yes
Handling Handle in accordance with good industrial hygiene and safety practice.
To Top