SDS
CofA
Description
A specific inhibitor of importin α/β-mediated nuclear import with no effect on a range of other nuclear import pathways1 . Displays potent antiviral activity against HIV-1, dengue1, corona2 and other viruses. Clinically useful broad-spectrum antiparasitic agent3.
Read more: Pathology Research Using Mitophagy Modulators
References
• "The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro"
• "Ivermectin in human medicine"
Not for human therapeutic use or for medicinal purposes. For research applications only.
More Information
Alternate Name/Synonyms
22,23-Dihydroavermectin B1; 22,23-Dihydro C076B1; MK-933
SKU
I-2570
CAS #
70288-86-7
Chemical Name
(1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15
Chemical Formula
C48H74O14
Molecular Weight
875.1 Da
Appearance
White powder
Purity
>98% (TLC)
Solubility
May be dissolved in DMSO (40 mg/mL)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
THERAPEUTIC AREA
Infectious diseases
USE
Coronavirus (COVID-19), HIV-1, Dengue, Viruses, Parasites
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product
Hazard Image
Yes
Certificate of Analysis 1
| GHS PICTOGRAMS |    |
|---|---|
| Handling | Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product |
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