IWP-2

SKU
I-2366
  • CAS:686770-61-6
  • Formula:C22H18N4O3S3
  • MW:466.6
  • Appearance:Beige Solid
  • Purity:98% by TLC
Product Name Qty
IWP-2
5 mg
$142.38
IWP-2
25 mg
$563.84
Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC= 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.
More Information
Alternate Name/Synonyms
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
SKU
I-2366
CAS #
686770-61-6
Chemical Name
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Chemical Formula
C22H18N4O3S3
Molecular Weight
466.6
Appearance
Beige Solid
Purity
98% by TLC
Solubility
DMSO (~5 mg/ml with warming)
Melting Point
316.82 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks β-catenin accumulation in gastric cancer.
MDL NUMBER
MFCD12912418
CHEMACX
X1763501-7
INCHI
InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
SMILES
Cc1ccc2c(c1)sc(n2)NC(=O)CSc3nc4c(c(=O)n3c5ccccc5)SCC4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
Handling Protect from light and air
UN #'S Not Applicable
Packing Group Not Applicable
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