JM6

SKU
J-2368
  • CAS:1008119-83-2
  • Formula:C23H26N4O6S2
  • MW:518.61
  • Appearance:Off-White Solid
  • Purity:98% by HPLC
Product Name Qty
JM6
5 mg
$117.25
JM6
25 mg
$441.11

Cell-permeable. A slow-release prodrug version of Ro 61-8048, an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimers and Huntingtons in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.

More Information
Alternate Name/Synonyms
2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole
SKU
J-2368
CAS #
1008119-83-2
Chemical Name
2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole
Chemical Formula
C23H26N4O6S2
Molecular Weight
518.61
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) prevents spatial memory deficits, anxiety-related behavior,Alzheimer disease
MDL NUMBER
MFCD22380618
CHEMACX
X5289403-0
INCHI
InChI=1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
SMILES
COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=C(S2)CN3CCCCC3)C4=CC(=CC=C4)[N+](=O)[O-])OC
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 2811
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Protect from light
Promo text for AGS discount
N/A
Handling Protect from light
UN #'S UN 2811
Packing Group III
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