- MW:467.5 Da
- Appearance:White powder
- Purity:>99% (HPLC)
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. A general protein kinase inhibitor. CaM, PKC , PKG , myosin light chain kinase .Attached is a published reference from researchers who have used our K-252a product.A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity.
Pharmacology: Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM)1 . Inhibits CaMK (Ki = 1.8 nM)2 and phosphorylase kinase (IC50 = 1.7 nM)3 as well as other kinases4 . Induces apoptosis . Cell permeable.
Fermentation product from Nocardiopsis sp.
|Handling||Hygroscopic. Protect from Light Protect from Moisture. Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|