K-252a

SKU
K-1006
  • CAS:99533-80-9
  • Formula:C27H21N3O5
  • MW:467.5 Da
  • Appearance:White powder
  • Purity:>99% (HPLC)

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1

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Product Name Qty
K-252a, Nocardiopsis sp.
25 mg
$1,249.99
K-252a, Nocardiopsis sp.
5 mg
$349.99
K-252a, Nocardiopsis sp.
1 mg
$89.99

Description

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. A general protein kinase inhibitor. CaM, PKC , PKG , myosin light chain kinase .Attached is a published reference from researchers who have used our K-252a product.A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity.

Applications

Pharmacology: Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM)1 . Inhibits CaMK (Ki = 1.8 nM)2 and phosphorylase kinase (IC50 = 1.7 nM)3 as well as other kinases4 . Induces apoptosis . Cell permeable.

 

Fermentation product from Nocardiopsis sp.

 

More Information
Alternate Name/Synonyms
SF 2370
SKU
K-1006
CAS #
99533-80-9
Chemical Name
(9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG-3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER
Chemical Formula
C27H21N3O5
Molecular Weight
467.5 Da
Appearance
White powder
Purity
>99% (HPLC)
Solubility
May be dissolved in DMSO (100 mg/mL)
Melting Point
256-258 °C
Preparation
N/A
Storage Temp
Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
THERAPEUTIC AREA
Oncological Disorders
USE
For research and laboratory use only.
Merck Index
N/A
MDL NUMBER
MFCD00161522
CHEMACX
X1286334-4
INCHI
InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
SMILES
C[C@@]12[C@](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)(C(=O)OC)O
Peptide sequence
Not Applicable
RTECS
NZ0550000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Hygroscopic. Protect from Light Protect from Moisture. Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Citations
PLANT BIOLOGY: A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity Dongping Lu, Shujing Wu, Xiquan Gao, Yulan Zhang, Libo Shan, and Ping He PNAS, Jan 2010; 107: 496 - 501.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/107/1/496
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Hygroscopic. Protect from Light Protect from Moisture. Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
UN #'S Not Applicable
Packing Group Not Applicable
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