K-252a

SKU
K-2502
  • CAS:99533-80-9
  • Formula:C27H21N3O5
  • MW:467.5
  • Appearance:Pale Yellow Powder
  • Purity:97%
Product Name Qty
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An analog of Staurosporine that acts as a non-selective protein kinase inhibitor. Iinhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Potently inhibits CaMK (Ki = 1.8 nM), competitively with ATP and noncompetitively with the substrate.

More Information
SKU
K-2502
CAS #
99533-80-9
Chemical Formula
C27H21N3O5
Molecular Weight
467.5
Appearance
Pale Yellow Powder
Purity
97%
Solubility
Soluble in Methylene Chloride and DMSO
Stability
N/A
Melting Point
256-258 °C
THERAPEUTIC AREA
Oncological Disorders
USE
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
MDL NUMBER
MFCD00161522
CHEMACX
X1486397-5
PubChecm ID
N/A
INCHI
InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
SMILES
C[C@@]12[C@](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)(C(=O)OC)O
RTECS
NZ0550000
Handling
Hygroscopic. Protect from Light Protect from Moisture.
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Handling Hygroscopic. Protect from Light Protect from Moisture.
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