Kainic Acid (synthetic)

SKU
K-1012
  • CAS:487-79-6
  • Formula:C10H15NO4
  • MW:213.2 Da
  • Appearance:White to off white crystalline powder
  • Purity:>98% (TLC)

2

1

0

0

Product Name Qty
Kainic Acid (synthetic)
10 mg
$128.45
Kainic Acid (synthetic)
5x10 mg
$558.36

Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, acting through specific kainate receptors and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is utilized in primary neuronal cell cultures and acute brain slice preparations to study the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics.

More Information
Alternate Name/Synonyms
(-)-a-Kainic Acid; Kainate; Digenic acid; Helminal; Digenin; Digensaeure; Kainsaeure
SKU
K-1012
CAS #
487-79-6
Chemical Name
(2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine)
Chemical Formula
C10H15NO4
Molecular Weight
213.2 Da
Appearance
White to off white crystalline powder
Purity
>98% (TLC)
Solubility
Soluble in water at 10 mg/mL
Melting Point
251°C
Storage Temp
Store desiccated at room temperature.
THERAPEUTIC AREA
Neurological disorders
USE
Kainic acid is a potent central nervous system excitant that is used in epilepsy
Merck Index
13.5294.2001
MDL NUMBER
MFCD00077806
CHEMACX
X1063761-9
INCHI
InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
SMILES
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
Handling
Store in a tightly-sealed vial. Protect from light.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Store in a tightly-sealed vial. Protect from light.
Citations BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development
Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy
EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability
Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response
Decreased levels of active uPA and KLK8 assessed by [111 In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy
Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons
Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein
Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures
Limbic system activation is affected by prenatal predator exposure and postnatal environmental enrichment and further moderated by dam and sex
Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats
An enhanced home cage modulates hypothalamic CRH-ir labeling in juvenile rats, with and without sub-threshold febrile convulsions
Glutamate Excitotoxicity In Epilepsy And Ischemia
Early Life Experiences Influence Seizure Susceptibility of 14-day Old Rat Pups in a Dam-dependent and Sex-dependent Manner
Targeting oxidative damage to attenuate cognitive deficits associated with epileptogenesis
In vivo measurement of brain network connectivity reflects progression and intrinsic disease severity in a model of temporal lobe epilepsy
To Top