Ketanserin (tartrate)

SKU
K-1044
  • CAS:83846-83-7
  • Formula:C22H22FN3O3 • C4H6O6
  • MW:545.5 Da
  • Appearance:Crystalline solid
  • Purity:≥98%

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Product Name Qty
Ketanserin (tartrate)
50 mg
$116.19

Description

Ketanserin tartrate is a salt of Ketanserin and acts as a selective 5-HT2 receptor antagonist. It is also called R 41 468.

Ketanserin is a selective serotonergic antagonist. It inhibits effects of serotonin and displays high affinity for G protein coupled receptor (GPCR) and ion channels in the central nervous system (CNS). It has no agonistic property in isolated vascular preparation.

It was determined that Ketanserin tartrate has antihypertensive properties, inhibiting serotonin-induced platelet aggregation and causing either relaxation or contraction of vascular smooth muscle.

According to a study, Ketanserin tartrate inhibits HMG CoA reductase activity in human skin fibroblasts. Inhibition of HMG CoA reductase activity generally induces upregulation of LDL receptor activity.

In addition, it has been reported that it reduces systolic and diastolic blood pressure without alteration of heart rates and only affects to low density lipoprotein (LDL)-cholesterol level reduced.

 

Applications

• Used for hypertension

• Study of Serotonin pharmacology

 

References

• “Ketanserin”

• “Vascular Effects of Ketanserin (R 41 468), A Novel Antagonist of 5-HT2 Serotonergic Receptors”

• “Effects of Ketanserin Tartrate on Serum Lipids in Patients with Essential Hypertension”

• “Effects of ketanserin tartrate on 3-hydroxy, 3-methylglutaryl coenzyme a reductase activity in cultured human skin fibroblasts” 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
3-[2-[4-(4-Fluorobenzoyl)-1-piperdinyl]ethyl]-2,4(1H,3H)-quinazolinedione; R 41 468; KJK-945; R 49945; 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione 2,3-dihydroxysuccinate; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
SKU
K-1044
CAS #
83846-83-7
Chemical Name
2,3-dihydroxybutanedioic acid;3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
Chemical Formula
C22H22FN3O3 • C4H6O6
Molecular Weight
545.5 Da
Appearance
Crystalline solid
Purity
≥98%
Solubility
Soluble in Water, DMSO, and Ethanol
Melting Point
183-186°C
Storage Temp
-20°C
THERAPEUTIC AREA
Psychological Disorders
USE
Selective 5-HT2 5-HT1C serotonin receptor antagonist.
MDL NUMBER
MFCD00084651
CHEMACX
X1192471-7
INCHI
InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
SMILES
c1ccc2c(c1)c(=O)n(c(=O)[nH]2)CCN3CCC(CC3)C(=O)c4ccc(cc4)F.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
RTECS
VA1411195
UN #'S
UN 2811
PACKING GROUP
III
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep container tightly closed.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep container tightly closed.
UN #'S UN 2811
Packing Group III
Citations Ketanserin
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