- Appearance:Pale yellow powder
- Purity:>98% by HPLC
*Please inquire the availability for this product. Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.
Pale yellow powder
>98% by HPLC
Soluble in ethanol, methanol, DMSO, and DMF
Kigamicin C and other kigamicins demonstrate cytotoxicity against PANC-1 pancreatic cancer cells