KN-93, Water-Soluble

SKU
K-1092
  • Formula:C26H29CIN2O4S H3PO4
  • MW:599
  • Appearance:White Solid
  • Purity:95%

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KN-93, Water-Soluble
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 A water-soluble form of the CaM kinase II inhibitor KN-93. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G cell cycle arrest and apoptosis in NIH 3T3 cells.

More Information
SKU
K-1092
Chemical Formula
C26H29CIN2O4S H3PO4
Molecular Weight
599
Appearance
White Solid
Purity
95%
Solubility
Soluble in H2O (5 mg/ml)
Storage Temp
+4°C
THERAPEUTIC AREA
Cardiological Disorders
USE
KN-93 potently inhibited myocardial CaM kinase activity
MDL NUMBER
MFCD03788201
CHEMACX
X7633487-7
INCHI
InChI=1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+;
SMILES
CN(C/C=C/c1ccc(cc1)Cl)Cc2ccccc2N(CCO)S(=O)(=O)c3ccc(cc3)OC.OP(=O)(O)O
Handling
Protect from Light Hygroscopic. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Handling Protect from Light Hygroscopic. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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