Ko-143

SKU
K-2013
  • CAS:461054-93-3
  • Formula:C26 H35 N3 O5
  • MW:469.578
  • Appearance:Solid
Product Name Qty
Ko-143
5 mg
$119.60

 BCRP inhibitor

More Information
SKU
K-2013
CAS #
461054-93-3
Chemical Formula
C26 H35 N3 O5
Molecular Weight
469.578
Appearance
Solid
Solubility
Soluble in DMSO (>25 mg/ml), ethanol (100 mM), and water
Melting Point
147 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell
MDL NUMBER
MFCD11042273
CHEMACX
X1722231-4
INCHI
InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
SMILES
CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
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