L-685, 458

SKU
L-2369
  • CAS:292632-98-5
  • Formula:C39H52N4O6
  • MW:672.85
  • Appearance:Liquid
  • Purity:98% by HPLC

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Product Name Qty
L-685, 458
250 g
$217.76
Cell-permeable. A potent and selective γ-secretase inhibitor (IC= 17 nM) .Displays 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A40 and A42 peptides (ICvalues are 48 and 67 nM respectively in human neuroblastoma cells).
More Information
Alternate Name/Synonyms
5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
SKU
L-2369
CAS #
292632-98-5
Chemical Name
5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Chemical Formula
C39H52N4O6
Molecular Weight
672.85
Appearance
Liquid
Purity
98% by HPLC
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Cell-permeable. A potent and selective γ-secretase inhibitor
MDL NUMBER
MFCD03093402
CHEMACX
X1270552-5
INCHI
InChI=1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32+,33+,34-/m1/s1
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N)NC(=O)[C@H](Cc2ccccc2)C[C@H]([C@H](Cc3ccccc3)NC(=O)OC(C)(C)C)O
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Certificate of Analysis 1
Promo text for AGS discount
N/A
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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