L-Quisqualic Acid

SKU
Q-1000
  • CAS:52809-07-1
  • Formula:C5H7N3O5
  • MW:189.13 Da
  • Appearance:White to off-white powder
  • Purity:≥98%

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Product Name Qty
L-Quisqualic Acid
5 mg
$94.99
L-Quisqualic Acid
10 mg
$164.99
L-Quisqualic Acid
25 mg
$349.99
L-Quisqualic Acid
1 mg
$49.99

Description

L-Quisqualic Acid is one of the most potent AMPA receptor agonists, causing excitotoxicity -- a process in which nerve cells are killed or damaged due to the overstimulation of neurotransmitters. It is also believed to mimic the excitatory neurotransmitter L-glutamic acid, which is studied in relation to insect neuromuscular function and the mammalian central nervous system.

Applications

Commonly used in neuroscience to deliberately kill brain and/or spinal cord neurons, L-Quisqualic Acid is also used to sensitize neurons to depolarization within the hippocampus (known as the "quis effect") -- which is the movement of a cell membrane's potential, making it slightly more positive.

 

More Information
Alternate Name/Synonyms
Quisqualic Acid; Quisqualate
SKU
Q-1000
CAS #
52809-07-1
Chemical Name
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Chemical Formula
C5H7N3O5
Molecular Weight
189.13 Da
Appearance
White to off-white powder
Purity
≥98%
Solubility
1 eq. NaOH to 100mM, water to 10mM
Storage Temp
4°C. Whenever possible, prepare and use solutions on the same day. If stock solutions are made in advance, they can be stored at -20°C for up to one month.
THERAPEUTIC AREA
Neurological Disorders
USE
L-Quisqualic Acid is used to test ligand-gated receptors in spiral ganglion neurons and to differentiate between mGluR-1 and mGluR-4. It also induces a slow K(+)-current response in B6 neurons of Aplysia buccal ganglia.
INCHI
InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
Handling
Whenever possible, prepare and use solutions on the same day. If stock solutions are made in advance, they can be stored at -20°C for up to one month. Ensure adequate ventilation.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Whenever possible, prepare and use solutions on the same day. If stock solutions are made in advance, they can be stored at -20°C for up to one month. Ensure adequate ventilation.
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