14-Hydroxyfilipin (Lagosin)

SKU
L-2525
  • CAS:6834-98-6
  • Formula:C35H58O12
  • MW:670.4
  • Appearance:Pale yellow to tan solid
  • Purity:>95% by HPLC
Product Name Qty
14-Hydroxyfilipin (Lagosin)
1 mg
$341.72
14-Hydroxyfilipin (Lagosin)
5 mg
$1,196.02

 Lagosin or 14-HYDROXYFILIPIN is a pentaene antifungal antibiotic produced by Streptomyces. It was first isolated in 1958 by researchers at MIT in the USA. Lagosin exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols.Structurally, lagosin is 14-hydroxyfilipin III and the most polar member of the filipin family of fungicides. 

In a recent study 14-HYDROXYFILIPIN was used to evaluate its efficacy on candida albicans biofilm formation. The results revealed that 14-HYDROXYFILIPIN  has an inhibitory effect on the formation of C. albicans biofilm in a dose-dependent manner with a minimum inhibitory concentration (MIC) of 10 µg/mL. It also showed that 14-HYDROXYFILIPIN could also induce the apoptosis of C. albicans cells in a dose-dependent manner. 

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More Information
Alternate Name/Synonyms
Fungichromin, Lagosin, Cogomycin, Moldcidin B, A246, Pentamycin
SKU
L-2525
CAS #
6834-98-6
Chemical Formula
C35H58O12
Molecular Weight
670.4
Appearance
Pale yellow to tan solid
Purity
>95% by HPLC
THERAPEUTIC AREA
Infectious Diseases
USE
Lagosin exhibits broad spectrum antifungal and antitumor activity
MDL NUMBER
MFCD01939601
INCHI
InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+
SMILES
CCCCCC(C1C(CC(CC(CC(CC(CC(C(C(/C(=C/C=C/C=C/C=C/C=C/C(C(OC1=O)C)O)/C)O)O)O)O)O)O)O)O)O
Certificate of Analysis 1
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