Lapatinib Ditosylate

SKU
L-2371
  • CAS:388082-78-8
  • Formula:C29H26ClFN4O4S.2C7H8O3S
  • MW:925.46
  • Appearance:Yellow Solid
  • Purity:99% by HPLC
Product Name Qty
Lapatinib Ditosylate
100 mg
$375.27
Lapatinib Ditosylate
25 mg
$160.05

Lapatinib is a potent inhibitor of EGFR kinase (K = 3 nM), ErbB-2 kinase (K = 13 nM), ErbB-4 kinase (K = 347 nM). Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive breast cancer models.

More Information
Alternate Name/Synonyms
GW-57201, Tykerb, Tyverb
SKU
L-2371
CAS #
388082-78-8
Chemical Name
BIS(4-METHYLBENZENE-1-SULFONIC ACID) N-(3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYL)-6-(5-([(2-METHANESULFONYLETHYL)AMINO]METHYL)FURAN-2-YL)QUINAZOLIN-4-AMINE
Chemical Formula
C29H26ClFN4O4S.2C7H8O3S
Molecular Weight
925.46
Appearance
Yellow Solid
Purity
99% by HPLC
Solubility
DMSO (200 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Lapatinib Ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases.
MDL NUMBER
MFCD09264195
CHEMACX
X1616542-3
INCHI
InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)
SMILES
O=S(=O)(O)c1ccc(cc1)C.O=S(=O)(O)c1ccc(cc1)C.Fc1cccc(c1)COc2ccc(cc2Cl)Nc5ncnc4c5cc(c3oc(cc3)CNCCS(=O)(=O)C)cc4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and moisture
HandlingProtect from air and moisture
UN #'SNot Applicable
Packing GroupNot Applicable
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