Latrunculin B, NSC 339663

SKU
L-1057
  • CAS:76343-94-7
  • Formula:C20H29NO5S
  • MW:395.5
  • Appearance:Lyophilized Solid
  • Purity:98%

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Product Name Qty
Latrunculin B
1 mg
$187.61

Latrunculin B is an actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture.Latrunculin B causes stress fibers toshortening and thicken.EffectsN1E-115 cells (mouse neuroblastoma) at starting concentrationsof 90 nM (NI43T3 cells, 0.9M). Maximumeffect at 2.5M. Fetal Bovine serum will slowly inactivate. Inhibitscofilin-actin binding (ED~50 M).Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent.Differential Involvement of the Actin Cytoskeleton in Differentiation and Mitogenesis of Thyroid Cells: Inactivation of Rho Proteins Contributes to Cyclic Adenosine Monophosphate-Dependent Gene Expression but Prevents Mitogenesis.A Role for Cytoskeletal Elements in the Light-Driven Translocation of Proteins in Rod Photoreceptors.The Potato Virus X TGBp2 Movement Protein Associates with Endoplasmic Reticulum-Derived Vesicles during Virus Infection.

More Information
Alternate Name/Synonyms
Latrunculin B, Actin filament modulator.
SKU
L-1057
CAS #
76343-94-7
Chemical Name
(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-HYDROXY-5,10-DIMETHYL-3-OXO-2,14-DIOXABICYCLO[11.3.1]HEPTADECA-4,8-DIEN-15-YL]-1,3-THIAZOLIDIN-2-ONE
Chemical Formula
C20H29NO5S
Molecular Weight
395.5
Appearance
Lyophilized Solid
Purity
98%
Solubility
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Melting Point
258.13 °C
Storage Temp
-20°C
USE
Latrunculin B is a structurally unique marine toxin
Merck Index
Merck Index: 14: 5378
MDL NUMBER
MFCD00270879
CHEMACX
X1000493-6
INCHI
InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13?,15-,16?,17-,20-/m1/s1
SMILES
CC/1CC[C@@H]2CC(C[C@@](O2)([C@H]3CSC(=O)N3)O)OC(=O)/C=C(CC/C=C1)/C
Handling
Warning.Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Store in Tightly Sealed Vial
Citations
MEMBRANE TRAFFICKING: Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes Juliane P. Caviston, Allison L. Zajac, Mariko Tokito, and Erika L.F. Holzbaur Mol. Biol. Cell, Feb 2011; 22: 478 - 492.
Citations_Hyperlink
http://www.molbiolcell.org/cgi/reprint/22/4/478
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Warning.Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Store in Tightly Sealed Vial
Citations Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively
The potato virus X TGBp2 movement protein associates with endoplasmic reticulum-derived vesicles during virus infection
Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis
Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes
The PXL1 gene of Saccharomyces cerevisiae encodes a paxillin-like protein functioning in polarized cell growth
Vasoconstrictor-induced endocytic recycling regulates focal adhesion protein localization and function in vascular smooth muscle
Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent
The potato virus X TGBp2 protein association with the endoplasmic reticulum plays a role in but is not sufficient for viral cell-to-cell movement
A role for cytoskeletal elements in the light-driven translocation of proteins in rod photoreceptors
Enhancement of the endosomal endocytic pathway increases quantal size
Actin filaments attachment at the plasma membrane in live cells cause the formation of ordered lipid domains
Focal adhesion protein dynamics and the role of endosomes in contractile, fully differentiated, vascular smooth muscle
Investigating the Role of Microtubules in Glut4 Vesicle Trafficking and the Kinetics of Membrane Attachment by the Myosin Myo1c
Subcellular Localization and Role of Potato Virus X (Pvx) Tgbp2 in Virus Cell-to-cell Movement
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