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Leptomycin A

SKU
L-2533
  • CAS:87081-36-5
  • Formula:C32H46O6
  • MW:526.70 Da
  • Appearance:Lyophilized powder
  • Purity:>98% by HPLC

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3

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SDS
CofA
Product Name Qty
Leptomycin A
1 mg
$433.50
Leptomycin A
5 mg
$1,683.00
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Description & Applications

Leptomycin A is a compound that, along with the better-known leptomycin B analogue, makes up the broader leptomycin complex produced by some Streptomyces species. Leptomycin B is a documented inhibitor of CRM1 and as a result is capable of significantly inhibiting nuclear export.

Leptomycin B also demonstrates a cytotoxic effect that is more pronounced in cancerous cells than in those functioning normally. This effect has led to research into leptomycin B as a potential therapy for lung cancer. As a closely related member of the complex, leptomycin A is likely to exert the same inhibitory effect on nuclear export. Leptomycin A has also been shown to have some effectiveness as an antifungal agent. Leptomycin A shows antimicroMSTl activity against Schizosaccaromyces pombe and Mucor rouxianus.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Jildamycin; Antibiotic ATS 1287A; Antibiotic PD 118607
SKU
L-2533
CAS #
87081-36-5
Chemical Name
(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Chemical Formula
C32H46O6
Molecular Weight
526.70 Da
Appearance
Lyophilized powder
Purity
>98% by HPLC
Solubility
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Antibiotic. For Research use only. Not for human or drug use. Not extracted from humans or animals.
MDL NUMBER
MFCD01711669
INCHI
InChI=1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+
SMILES
CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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