Leptomycin A

SKU
L-2533
  • CAS:87081-36-5
  • Formula:C32H46O6
  • MW:526.7 Da
  • Appearance:Colorless film
  • Purity:>95% by HPLC

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Product Name Qty
Leptomycin A
1 mg
$439.99
Leptomycin A
5 mg
$1,599.99

Description & Applications

Leptomycin A is a compound that, along with the better-known leptomycin B analogue, makes up the broader leptomycin complex produced by some Streptomyces species. Leptomycin B is a documented inhibitor of CRM1 and as a result is capable of significantly inhibiting nuclear export. Leptomycin B also demonstrates a cytotoxic effect that is more pronounced in cancerous cells than in those functioning normally. This effect has led to research into leptomycin B as a potential therapy for lung cancer. As a closely related member of the complex, leptomycin A is likely to exert the same inhibitory effect on nuclear export. Leptomycin A has also been shown to have some effectiveness as an antifungal agent. Leptomycin A shows antimicroMSTl activity against Schizosaccaromyces pombe and Mucor rouxianus.

More Information
Alternate Name/Synonyms
Jildamycin, NSC 369326, ATS 1287A, PD 118607
SKU
L-2533
CAS #
87081-36-5
Chemical Name
(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Chemical Formula
C32H46O6
Molecular Weight
526.7 Da
Appearance
Colorless film
Purity
>95% by HPLC
Solubility
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
For Research use only. Not for Human or Drug use. Not extracted from humans or animals
MDL NUMBER
MFCD01711669
INCHI
InChI=1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+
SMILES
CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
Handling
Flammable product; KEEP AWAY FROM THE HEAT SOURCE! Use in ventilated area. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
GHS PICTOGRAMS
Handling Flammable product; KEEP AWAY FROM THE HEAT SOURCE! Use in ventilated area. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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