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Leptomycin B

SKU
L-1069
  • CAS:87081-35-4
  • Formula:C33H48O6
  • MW:540.7 Da
  • Appearance:Colorless film
  • Purity:>99% by HPLC

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SDS
CofA
Product Name Qty
Leptomycin B
2.5 mg
$867.00
Leptomycin B
0.5 mg
$249.90
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Description

Leptomycin B is an antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal anti-tumor activity.

Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Mantuamycin; Antibiotic CI 940; Elactocin; LMB
SKU
L-1069
CAS #
87081-35-4
Chemical Name
(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Chemical Formula
C33H48O6
Molecular Weight
540.7 Da
Appearance
Colorless film
Purity
>99% by HPLC
Solubility
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Leptomycin B is an anti-fungal antibiotic that is used for studying nuclear localization and nuclear export.
Merck Index
Merck Index: 13.5463.2001
MDL NUMBER
MFCD06795848
CHEMACX
X1461547-9
INCHI
InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Peptide sequence
Not Applicable
UN #'S
3077
PACKING GROUP
III
HAZARD CLASS
9
Handling
Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Certificate of Analysis 1
L-1069, H1127.pdf
Certificate of Analysis 2
L-1069, G1211.pdf
Certificate of Analysis 3
L-1069, B1766.pdf
GHS PICTOGRAMS
Handling Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
UN #'S 3077
Packing Group III
Citations The POU protein Oct-6 is a nucleocytoplasmic shuttling protein
Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase
Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope
VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway
NOVEL MECHANISMS IN THE REGULATION OF PERINUCLEAR ACTIN ASSEMBLY
Intrazelluläre Zielsteuerung der humanen Inositol-1, 4, 5-trisphosphat 3-Kinase Isoform B
Intrazelluläre Zielsteuerung der humanen Inositol-1,4,5-trisphosphat 3-Kinase Isoform B
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