Leptomycin B

SKU

L-1069

CAS:87081-35-4
Formula:C₃₃H₄₈O₆
MW:540.7 Da
Appearance:Colorless film
Purity:>99% by HPLC

SDS

CofA

Product Name	Qty
Leptomycin B 0.5 mg $348.42
Leptomycin B 2.5 mg $1,150.00

Details

Antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal anti-tumor activity.

Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.

Specifications

More Information

Alternate Name/Synonyms

Mantuamycin; Antibiotic CI 940; Elactocin; LMB; ATS 1287B; CI 940; CL 1957A; PD 114720

SKU

L-1069

CAS #

87081-35-4

Chemical Name

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid

Chemical Formula

C₃₃H₄₈O₆

Molecular Weight

540.7 Da

Appearance

Colorless film

Purity

>99% by HPLC

Solubility

Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.

Storage Temp

-20°C

THERAPEUTIC AREA

Infectious Diseases

USE

Leptomycin B is an anti-funga antibiotic that is used for studying nuclear localization and nuclear export.

Merck Index

Merck Index: 13.5463.2001

MDL NUMBER

MFCD06795848

CHEMACX

X1461547-9

INCHI

InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1

SMILES

CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C

Peptide sequence

Not Applicable

UN #'S

3077

PACKING GROUP

III

HAZARD CLASS

Handling

Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.

Certificate of Analysis 1

L-1069, H1127.pdf

Certificate of Analysis 2

L-1069, G1211.pdf

Certificate of Analysis 3

L-1069, B1766.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
UN #'S	3077
Packing Group	III

Citations

Citations	The POU protein Oct-6 is a nucleocytoplasmic shuttling protein
	Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase
	Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope
	VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway
	NOVEL MECHANISMS IN THE REGULATION OF PERINUCLEAR ACTIN ASSEMBLY
	Intrazelluläre Zielsteuerung der humanen Inositol-1, 4, 5-trisphosphat 3-Kinase Isoform B
	Intrazelluläre Zielsteuerung der humanen Inositol-1,4,5-trisphosphat 3-Kinase Isoform B

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