Leucinostatin A

SKU
L-2539
  • CAS:76600-38-9
  • Formula:C62H111N11O13
  • MW:1218.6
  • Appearance:Light tan to tan solid
  • Purity:>95% by HPLC
Product Name Qty
Leucinostatin A
25 mg
$673.29
Leucinostatin A
0.5 mg
$193.16
*Please inquire the availability for this product. Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumor cell lines. Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.
More Information
Alternate Name/Synonyms
Tryanocidin, CC 1014, M 13959, ML 1014, P 168, SF 1907VIII, U 53496
SKU
L-2539
CAS #
76600-38-9
Chemical Formula
C62H111N11O13
Molecular Weight
1218.6
Appearance
Light tan to tan solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF, DMSO, and water (limitedly)
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells
INCHI
InChI=1S/C62H111N11O13/c1-21-38(9)23-24-49(77)73-33-40(11)31-47(73)55(82)66-46(30-39(10)29-43(75)32-42(74)22-2)53(80)68-50(51(78)37(7)8)56(83)70-61(15,16)58(85)67-44(27-35(3)4)52(79)65-45(28-36(5)6)54(81)69-62(17,18)59(86)71-60(13,14)57(84)63-26-25-48(76)64-41(12)34-72(19)20/h23-24,35-41,43-47,50-51,75,78H,21-22,25-34H2,1-20H3,(H,63,84)(H,64,76)(H,65,79)(H,66,82)(H,67,85)(H,68,80)(H,69,81)(H,70,83)(H,71,86)/b24-23+
SMILES
CCC(C)/C=C/C(=O)N1CC(CC1C(=O)NC(CC(C)CC(CC(=O)CC)O)C(=O)NC(C(C(C)C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)NC(C)CN(C)C)C
Promo text for AGS discount
N/A
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