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Lincomycin

SKU
L-2553
  • CAS:154-21-2
  • Formula:C18H34N2O6S
  • MW:406.5
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Lincomycin
5 mg
$151.48
Lincomycin
25 mg
$529.03
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Description

Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity.

Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Linocin; Lincolnensin; U 10149; Jiemycin; Lincomycinum; Cillimycin; Lincomycin A
SKU
L-2553
CAS #
154-21-2
Chemical Name
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
Chemical Formula
C18H34N2O6S
Molecular Weight
406.5
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF, DMSO, and water
Melting Point
262.24 °C
Storage Temp
-20ºC
THERAPEUTIC AREA
Infectious Diseases
USE
Lincomycin broad spectrum antibiotic with activity against anaerobic bacteria and protozoans
MDL NUMBER
MFCD00864895
INCHI
InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
SMILES
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O
Handling
Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
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