Locostatin, Cell Sheet Migration Inhibitor
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A cell-permeable potent inhibitor of Raf kinase inhibitor protein (RKIP) with Raf1 kinase interaction. Blocks eukaryotic cell migration (IC₅₀ = 14 µM for inhibition of wound closure in MDCK cell monolayers) and decrease formation of lamellipodial protrusions at wound margins. Inhibits early development in frog embryos and tissue dynamics in embryonic explants. No antibacterial activity displayed.