LY-333531

SKU
L-1011
  • CAS:169939-93-9
  • Formula:C28H28N4O3.HCl
  • MW:504.5
  • Appearance:Red to Orange Solid
  • Purity:98%
Product Name Qty
LY-333531
5 mg
$654.97
LY-333531
1 mg
$176.55
Potent, selective inhibitor of Protein Kinase C isozymes, PKC I(IC50=4.7 nM) and PKC II (IC50=5.9 nM)..Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C II.Role of p90 Ribosomal S6 Kinase (p90RSK) in Reactive Oxygen Species and Protein Kinase C (PKC-)-mediated Cardiac Troponin I Phosphorylation.PKC- is upstream and PKC- is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium.Vascular Endothelial Growth Factor Induces MEF2C and MEF2-Dependent Activity in Endothelial Cells.Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.
More Information
Alternate Name/Synonyms
Ruboxistaurin, (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
SKU
L-1011
CAS #
169939-93-9
Chemical Name
(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiaza-cyclohexadecene-1,3(2H)-dione. hydrochloride
Chemical Formula
C28H28N4O3.HCl
Molecular Weight
504.5
Appearance
Red to Orange Solid
Purity
98%
Solubility
Soluble in DMSO, Slightly soluble in 100% ethanol or water
Storage Temp
+4°C
THERAPEUTIC AREA
Ophthalmological Disorders
USE
LY333531 is a potent inhibitor of protein kinase Cß use in diabetic. LY333531 improves blood flow and leukocyte entrapment in the retina
MDL NUMBER
MFCD00940226
CHEMACX
X1704593-1
INCHI
InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
SMILES
CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Protect from Moisture.
Citations
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY: UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin IIbβ3 Robin Verhaar, David W. C. Dekkers, Iris M. De Cuyper, Mark H. Ginsberg, Dirk de Korte, and Arthur J. Verhoeven Blood, Dec 2008; 112: 4935 - 4939.
Citations_Hyperlink
http://bloodjournal.hematologylibrary.org/cgi/reprint/112/13/4935
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingStore in Tightly Sealed Vial Protect from Moisture.
UN #'SNot Applicable
Packing GroupNot Applicable
CitationsProtein kinase C mediates platelet secretion and thrombus formation through protein kinase D2
PKCalpha regulates platelet granule secretion and thrombus formation in mice
TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos
Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes
Cross talk between serine/threonine and tyrosine kinases regulates ADP-induced thromboxane generation in platelets
Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin
Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets
Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms
Protein kinase C delta is required for survival of cells expressing activated p21RAS
Protein kinase D activation stimulates the transcription of the insulin receptor gene
Identification of ERK and JNK as signaling mediators on protein kinase C activation in cultured granulosa cells
Vascular endothelial growth factor induces MEF2C and MEF2-dependent activity in endothelial cells
Receptor-mediated catecholamine release from chromaffin cells: the role of protein kinase C
A quantitative analysis of kinase inhibitor selectivity
PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium
Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin IIb 3
Human biliverdin reductase, a previously unknown activator of protein kinase C betaII
A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration
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