
LY294002 EZ SOLUTION is a 10 mM (5 mg/1627 µl) solution of PI -3 Kinase inhibitor
LY-294002 EZ SOLUTION is a cell-permeable, potent and specific phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor that acts on the ATP-binding site of the enzyme (IC50 = 1.4 µM). Also inhibits nonhomologous DNA end-joining (NHED) in the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase.
LY-294002 does not affect the activity of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase, and c-src at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Reported to inhibit histamine secretion in RBL-2H3 cells (IC50 = 5 µM).
More Information
Alternate Name/Synonyms
LY-294002 Solution
SKU
E-2312
CAS #
154447-36-6
Chemical Name
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Chemical Formula
C19H17NO3
Molecular Weight
307.34
Appearance
Clear colorless solution
Purity
≥98% by HPLC
Storage Temp
-20°C
Citations
RESEARCH ARTICLES:
Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase
Jian Zuo, Sandra Vergara, Shinya Kohno, and L. Shannon Holliday
J. Exp. Biol., Apr 2008; 211: 1102 - 1108.
Citations_Hyperlink
http://jeb.biologists.org/cgi/reprint/211/7/1102
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