MAFP (Methyl Arachidonyl Fluorophosphonate)

SKU
M-1247
  • CAS:188404-10-6
  • Formula:C21H36FO2P
  • MW:370.5 Da
  • Appearance:Yellow Oil
  • Purity:≥98%

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Product Name Qty
MAFP (Methyl Arachidonyl Fluorophosphonate)
10 mg
$205.00
MAFP (Methyl Arachidonyl Fluorophosphonate)
5 mg
$115.00
MAFP (Methyl Arachidonyl Fluorophosphonate)
1 mg
$55.00

Description

Methyl arachidonyl fluorophosphonate (MAFP) is a selective, active-site directed, irreversible inhibitor of cPLA2 and iPLA2. It inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 0.6 µM.

The IC50 value for inhibition of iPLA2 from P388D1 cells is 0.5 µM.2 MAFP is a potent inhibitor of fatty acid amide hydrolase, exhibiting an IC50 value of 2.5 nM. MAFP also binds to the CB1 receptor in rat brain membrane preparations. The IC50 values for MAFP and arachidonyl ethanolamide in this assay are 20 and 40 nM, respectively.

Supplied as a solution in methyl acetate.


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Methyl Arachidonyl Fluorophosphonate; MAFP
SKU
M-1247
CAS #
188404-10-6
Chemical Name
(5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
Chemical Formula
C21H36FO2P
Molecular Weight
370.5 Da
Appearance
Yellow Oil
Purity
≥98%
Storage Temp
-20°C
USE
MAFP is an irreversible inhibitor of cPLA2
INCHI
KWKZCGMJGHHOKJ-ZKWNWVNESA-N
SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(F)(OC)=O
UN #'S
1231
PACKING GROUP
II
HAZARD CLASS
3
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep away from sources of ignition. Take precautionary measures against static discharge.
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep away from sources of ignition. Take precautionary measures against static discharge.
UN #'S 1231
Packing Group II
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