Methyl arachidonyl fluorophosphonate (MAFP) is a selective, active-
The IC50 value for inhibition of iPLA2 from P388D1 cells is 0.5 µM.2 MAFP is a potent inhibitor of fatty acid amide hydrolase, exhibiting an IC50 value of 2.5 nM. MAFP also binds to the CB1 receptor in rat brain membrane preparations. The IC50 values for MAFP and arachidonyl ethanolamide in this assay are 20 and 40 nM, respectively.
Supplied as a solution in methyl acetate.
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep away from sources of ignition. Take precautionary measures against static discharge.|