Memantine Hydrochloride

SKU
M-1024
  • CAS:41100-52-1
  • Formula:C12H21N•HCl
  • MW:215.8 Da
  • Appearance:White powder
  • Purity:≥90 %

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Product Name Qty
Memantine Hydrochloride
10 mg
$25.70
Memantine Hydrochloride
50 mg
$72.59

Description

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist, that stimulates dopamine release. Memantine hydrochloride (1-amino3, 5-dimethyladamantane hydrochloride) is a tricyclic amine chemically and pharmacologically related to the anti-viral prototype amantadine and its α-methyl derivative rimantadine.

Memantine is used in Parkinson’s disease and movement disorders. Memantine hydrochloride is currently known as the latest treatment for moderate-to-severe Alzheimer disease (AD). The drug acts by noncompetitively binding to the N-methyl d-aspartate (NMDA) receptors of neurons in brain tissue to prevent overstimulation by glutamate. When this excitatory neurotransmitter over activates NMDA receptors in a tonic manner, an excessive influx of neurotoxic calcium ions follows. The resultant excitotoxicity may play a role in the impairment of memory and cognition in AD. Because memantine has a low-to-moderate affinity for NMDA receptors, it does not seem to block normal glutamate transmission; rather, it reduces abnormal neurotransmitter-mediated activation of the receptors, thereby potentially reducing excitotoxic neuronal damage. This form of neuroprotection may explain the improved cognition in patients with AD. 

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More Information
Alternate Name/Synonyms
Memantine HCl; Akatinol; Axura; Namenda; Ebix; 1-Amino-3,5-dimethyladamantane Hydrochloride
SKU
M-1024
CAS #
41100-52-1
Chemical Name
3,5-dimethyladamantan-1-amine;hydrochloride
Chemical Formula
C12H21N•HCl
Molecular Weight
215.8 Da
Appearance
White powder
Purity
≥90 %
Solubility
Soluble in Ethanol
Melting Point
N/A
Preparation
N/A
Storage Temp
Room temperature
THERAPEUTIC AREA
Neurological Disorders
USE
Memantine hydrochloride acts as a low-affinity NMDA receptor antagonist, binding to the ion channel site. It stimulates dopamine release.
Merck Index
N/A
MDL NUMBER
MFCD00214336
CHEMACX
X1093464-4
INCHI
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
Peptide sequence
Not Applicable
RTECS
YD1958750
Handling
Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
GHS PICTOGRAMS
Handling Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
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