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MES Monohydrate

SKU
M-1219
  • CAS:145224-94-8
  • Formula:C6H13NO4S • H2Oc
  • MW:213.24 Da
  • Appearance:White crystalline powder
  • Purity:≥99.0%
Product Name Qty
MES Monohydrate
50 g
$67.81
MES Monohydrate
250 g
$182.60
MES Monohydrate
500 g
$354.77
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Description

MES monohydrate is a zwitterionic, N-substituted aminosulfonic acid Good’s buffer. This biological buffer is used to attain desired pH concentrations in buffers. It lacks the ability to form a complex with most metal ions, so it is employed as a non-coordinating buffer in solutions with metal ions.

It has been reported that MES monohydrate is used to mimic the acidic tumor microenvironment to observe the effects of acidification on lung cancer cell viability.  

• pKa (20°C): 6.15
• pH range: 5.5 - 6.7
• Chloride (Cl): ≤0.01%
• Heavy Metals: ≤0.0010%
• Insoluble Matter: Pass (Filter Test)
• Iron: ≤0.0010%
• Loss on Drying: 7.0 - 10.0%
• pH: 2.5 - 4.0
• pKa @20°C: 6.02 - 6.25
• Solubility (10% solution in water): Clear
• UV Absorbance 250nm in 10% water: ≤0.05

 

Applications

• Cell culture media
• Running buffer in electrophoresis
• Protein purification chromatography
• Buffered culture media for bacteria/yeast

 

References

• “Plant regeneration from protoplast-derived callus of rice (Oryza sativa L.)”

• “Plant regeneration from protoplasts of Japanese lawngrass”

• “Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
2-(N-Morpholino)ethanesulfonic acid; 4-Morpholineethanesulfonic acid monohydrate; MES Hydrate Buffer
SKU
M-1219
CAS #
145224-94-8
Chemical Name
2-morpholin-4-ylethanesulfonic acid;hydrate
Chemical Formula
C6H13NO4S • H2Oc
Molecular Weight
213.24 Da
Appearance
White crystalline powder
Purity
≥99.0%
Solubility
Water (10% in H2O)
Melting Point
316 °C
Storage Temp
Room temperature
THERAPEUTIC AREA
Not Available
USE
MES is a biological buffer often referred to as a “Good’s” buffer .The pKa of MES is 5.96 which makes MES an ideal candidate for cell culture media and protein based buffer formulations to maintain a stable environment in solution. MES is considered to be non-toxic to culture cell lines, highly water soluble and provides high solution clarity. It is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream), and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins, blood components and growth factors.
MDL NUMBER
MFCD00006181
CHEMACX
X1009953-3
INCHI
MIIIXQJBDGSIKL-UHFFFAOYSA-N
SMILES
C1COCCN1CCS(=O)(=O)O
Peptide sequence
Not Applicable
RTECS
QE3479500
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
M-1219, MES Buffer, SDS, diamond format, r01, 2020.pdf
Certificate of Analysis 1
M-1219, L1011 r01.pdf
Certificate of Analysis 2
M-1219, J1276.pdf
Certificate of Analysis 3
M-1219, H1250B.pdf
GHS PICTOGRAMS
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
UN #'SNot Applicable
Packing GroupNot Applicable
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