MF-438, SCD1 inhibitor

SKU
M-3329
  • CAS:921605-87-0
  • Formula:C19H18F3N5OS
  • MW:421.44
  • Appearance:Off-white solid
  • Purity:98% by HPLC NMR (Confirms)
Product Name Qty
MF-438, SCD1 inhibitor
25 mg
$266.86

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50= 2.3 nM. MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg). Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model. MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

More Information
SKU
M-3329
CAS #
921605-87-0
Chemical Name
2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
Chemical Formula
C19H18F3N5OS
Molecular Weight
421.44
Appearance
Off-white solid
Purity
98% by HPLC NMR (Confirms)
Solubility
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Storage Temp
-20°
Hazard Image
Yes
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