MG-115

SKU
M-1155
  • CAS:133407-86-0
  • Formula:C25H39N3O5
  • MW:461.6 Da
  • Appearance:White lyophilized powder
  • Purity:≥95% (HPLC)

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Product Name Qty
MG-115
1 mg
$68.00
MG-115
5 mg
$185.00

Description

MG-115 is a potent, reversible inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells.

 

More Information
Alternate Name/Synonyms
MG115; Z-Leu-Leu-Nva-aldehyde; Z-LL-Nva-CHO; Z-Leu-Leu-Norvalinal; Z-LLnV; carbobenzoxy-leucyl-leucyl-norvalinal; Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal
SKU
M-1155
CAS #
133407-86-0
Chemical Name
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Chemical Formula
C25H39N3O5
Molecular Weight
461.6 Da
Appearance
White lyophilized powder
Purity
≥95% (HPLC)
Solubility
DMSO
Melting Point
278.81 °C
Storage Temp
-20°C
USE
Specifically inhibits the chymotrypsin-like activity of the proteasome.
MDL NUMBER
MFCD00671410
CHEMACX
X1088535-5
INCHI
InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
SMILES
CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Peptide sequence
Z-LEU-LEU-NORVALINAL
Handling
Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
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