Micrococcin P1, 0.5 MG

Micrococcin P1 holds the remarkable position in antibiotic discovery as the first of the early antibiotics to be lost to science. Micrococcin P1 is a thiopeptide originally isolated from Micrococcus sp. by Su at Oxford in 1948. Later, Heatley and Doery purified micrococcin and defined its physico-chemical properties and activity. The producing strain was lost, causing a hiatus in research of this antibiotic family until the discovery of the related thiocillins in 1976.
 

Micrococcin P1 demonstrates potent antimicrobial activity against bacteria, fungi, and even protozoa. Because it is a thiopeptide, Micrococcin P1(MP1) hold the potential for natural product engineering and avoid the growing concern of antibiotic resistance.