SDS
CofA
Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.
More Information
Alternate Name/Synonyms
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
SKU
M-2379
CAS #
478336-92-4
Chemical Name
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester
Chemical Formula
C12H13NO4
Molecular Weight
235.24
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (~25 mg/ml)
Melting Point
133.69 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Endocrinological Disorders
USE
MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic
MDL NUMBER
MFCD22376813
CHEMACX
X4983373-6
INCHI
InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
SMILES
COC(=O)CC1CC(=NO1)c2ccc(cc2)O
Handling
Protect from air and light
| GHS PICTOGRAMS |  |
|---|---|
| Handling | Protect from air and light |
