Milbemycin A3 oxime

SKU
M-2587
  • CAS:114177-14-9
  • Formula:C31H43NO7
  • MW:541.7 Da
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Milbemycin A3 oxime
1 mg
$349.58
Milbemycin A3 oxime
5 mg
$1,223.53

Description

Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
5-Oxomilbemycin A3 oxime
SKU
M-2587
CAS #
114177-14-9
Chemical Name
(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,24S)-24-hydroxy-21-hydroxyimino-5',6',11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Chemical Formula
C31H43NO7
Molecular Weight
541.7 Da
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Antibiotic
USE
The minor component of the anti-parasitic product milbemycin oxime
MDL NUMBER
MFCD21363714
INCHI
InChI=1S/C31H43NO7/c1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b7-6+,19-9+,23-8+,32-27?/t18-,20-,22+,24+,25?,26?,28+,30-,31+/m0/s1
SMILES
C[C@H]1CC[C@]2(CC3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]5[C@@]4(C(C=C(C5=NO)C)C(=O)O3)O)C)\C)O[C@@H]1C
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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