Milbemycin A4

SKU
M-2589
  • CAS:51596-11-3
  • Formula:C32H46O7
  • MW:542.3 Da
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Milbemycin A4
1 mg
$412.50
Milbemycin A4
5 mg
$1,443.76

Description

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A4 is the dominant member of a group of analogues containing a 25-ethyl substituent. Milbemycin A4 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act by opening glutamate sensitive chloride channels.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
B 41A4; Milbemycin alpha3; Milbemectin A4
SKU
M-2589
CAS #
51596-11-3
Chemical Name
(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21R,24S)-6'-ethyl-21,24-dihydroxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Chemical Formula
C32H46O7
Molecular Weight
542.3 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Antibiotic
USE
A highly selective and potent nematocide and insecticide
MDL NUMBER
MFCD04972570
INCHI
InChI=1S/C32H46O7/c1-6-27-21(4)12-13-31(39-27)17-25-16-24(38-31)11-10-20(3)14-19(2)8-7-9-23-18-36-29-28(33)22(5)15-26(30(34)37-25)32(23,29)35/h7-10,15,19,21,24-29,33,35H,6,11-14,16-18H2,1-5H3/b8-7+,20-10+,23-9+/t19-,21-,24+,25-,26-,27+,28+,29+,31+,32+/m0/s1
SMILES
CC[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)\C)C
Handling
Handle in accordance with good industrial hygiene and safety practice.
GHS PICTOGRAMS
HandlingHandle in accordance with good industrial hygiene and safety practice.
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