Milbemycin A4 oxime

SKU
M-2591
  • CAS:93074-04-5
  • Formula:C32H45NO7
  • MW:555.7 Da
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Milbemycin A4 oxime
1 mg
$349.58
Milbemycin A4 oxime
5 mg
$1,223.53

Description

Milbemycin A4 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A4. Milbemycin A4 oxime is the major component (~70%) in the commercial product, milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A4 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
5-Oxomilbemycin A4 oxime; Milbemycin A4 5-oxime
SKU
M-2591
CAS #
93074-04-5
Chemical Name
(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,24S)-6'-ethyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Chemical Formula
C32H45NO7
Molecular Weight
555.7 Da
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
USE
The major component of the anti-parasitic product milbemycin oxime
MDL NUMBER
MFCD21363715
INCHI
InChI=1S/C32H45NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3/b8-7+,20-10+,23-9+,33-28-/t19-,21-,24+,25-,26-,27+,29+,31+,32+/m0/s1
SMILES
O=C5O[C@H]2C[C@H](O[C@]1(O[C@H](CC)[C@@H](C)CC1)C2)C/C=C(\C)C[C@H](/C=C/C=C3/[C@@]4(O)[C@H]5\C=C(/C(=N/O)[C@H]4OC3)C)C
To Top