Milbemycin oxime

SKU
M-2595
  • CAS:129496-10-2
  • Formula:C32H45NO7
  • MW:555.7 Da
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Milbemycin oxime
5 mg
$151.48
Milbemycin oxime
25 mg
$529.03

Description

Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs, such as heartworms. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
SKU
M-2595
CAS #
129496-10-2
Chemical Formula
C32H45NO7
Molecular Weight
555.7 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Anti-parasitic, Veterinary medicine
USE
Milbemycin oxime is a veterinary drug from the group of milbemycins, used as a broad spectrum antiparasitic
MDL NUMBER
MFCD09038910
INCHI
InChI=1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b8-7+,20-10+,23-9+,33-28-;7-6+,19-9+,23-8+,32-27-/t19-,21-,24+,25-,26-,27+,29+,31+,32+;18-,20-,22+,24+,25-,26-,28+,30-,31+/m00/s1
SMILES
CC[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)C.C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)\C)O[C@@H]1C
Handling
Handle in accordance with good industrial hygiene and safety practice.
HandlingHandle in accordance with good industrial hygiene and safety practice.
To Top