Mito-Photo-DNP, Mitochondria specific, photo-activated protonophore
- Appearance:Pale yellow solid
- Purity:98% by TLC NMR (Conforms)
Mito-Photo-DNP is a mitochondria-targeted, photo-activated protonophore. This novel tool consists of three structural units, a caged protonophore, a photocleavable linker coupled to a triphenylphosphonium moiety which confers selective uptake by the mitochondria. Cells are treated with Mito-Photo-DNP at 200 nM and irradiated with UV light at 355 nm. Mito-Photo-DNP can be employed for selective uncoupling of either individual or a small number of mitochondria within a cell when used with fluorescence imaging.
- Used for research studies, to manipulate mitochondrial function;
- To release bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.